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31 P MR spectroscopic imaging combined with 1 H MR spectroscopic imaging in the human prostate using a double tuned endorectal coil at 7T
Author(s) -
Luttje Mariska P.,
Italiaander Michel G. M.,
Arteaga de Castro Catalina S.,
Kemp Wybe J. M.,
Luijten Peter R.,
Vulpen Marco,
Heide Uulke A.,
Klomp Dennis W. J.
Publication year - 2014
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25070
Subject(s) - magnetic resonance spectroscopic imaging , phosphocreatine , electromagnetic coil , nuclear magnetic resonance , radiofrequency coil , imaging phantom , creatine , nuclear medicine , in vivo , choline , magnetic resonance imaging , prostate , phosphocholine , prostate cancer , chemistry , radiology , phospholipid , phosphatidylcholine , cancer , medicine , physics , biochemistry , microbiology and biotechnology , quantum mechanics , membrane , biology , energy metabolism
Purpose Improved diagnostic sensitivity could be obtained in cancer detection and staging when individual compounds of the choline pool can be detected. Therefore, a novel coil design is proposed, providing the ability to acquire both 1 H and 31 P magnetic resonance spectroscopic imaging (MRSI) in patients with prostate cancer. Methods A two‐element 1 H/ 31 P endorectal coil was designed by adjusting a commercially available 3T endorectal coil. The two‐element coil setup was interfaced as a transceiver to a whole body 7T MR scanner. Simulations and phantom measurements were performed to compare the efficiency of the coil. 1 H MRSI and 31 P MRSI were acquired in vivo in prostate cancer patients. Results The efficiency of the 1 H/ 31 P coil is comparable to the dual channel 1 H coil previously published. Individually distinguishable phospholipid metabolites in the in vivo 31 P spectra were: phosphoethanolamine, phosphocholine, phosphate, glycerophosphoethanolamine, glycerophosphocholine, phosphocreatine, and adenosine triposphate. 1 H MRSI was performed within the same scan session, visualizing choline, polyamines, creatine, and citrate. Conclusion 1 H MRSI and 31 P MRSI can be acquired in the human prostate at 7T within the same scan session using an endorectal coil matched and tuned for 1 H (quadrature) and 31 P (linear) without the need of cable traps and with negligible efficiency losses in the 1 H and 31 P channel. Magn Reson Med 72:1516–1521, 2014. © 2013 Wiley Periodicals, Inc.