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In vivo waveguide elastography: Effects of neurodegeneration in patients with amyotrophic lateral sclerosis
Author(s) -
Romano Anthony,
Guo Jing,
Prokscha Torben,
Meyer Thomas,
Hirsch Sebastian,
Braun Jürgen,
Sack Ingolf,
Scheel Michael
Publication year - 2014
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25067
Subject(s) - magnetic resonance elastography , amyotrophic lateral sclerosis , diffusion mri , elastography , fractional anisotropy , medicine , anisotropy , magnetic resonance imaging , neurodegeneration , nuclear magnetic resonance , biomedical engineering , nuclear medicine , pathology , radiology , physics , ultrasound , optics , disease
Purpose Waveguide elastography (WGE) combines magnetic resonance elastography (MRE), diffusion tensor imaging (DTI), and anisotropic inversions for a determination of the elastic properties of white matter. Previously, the method evaluated the anisotropic elastic properties of the corticospinal tracts (CSTs) of healthy volunteers. Here, the sensitivity of WGE is tested for the detection of pathologic changes in a cohort of patients with Amyotrophic Lateral Sclerosis (ALS). Methods MRE and DTI were performed in 14 patients with ALS and 14 healthy, age‐matched controls. A comparison was made between three components from WGE and the DTI metrics FA, MD, PD, and RD, for the detection of differences between patients and controls. It was hypothesized that the stiffness values in the CSTs of the patients would be significantly lower due to the known neurodegeneration associated with ALS. Results Two anisotropic shear moduli polarized parallel and perpendicular to the CSTs were significantly reduced in ALS patients ( P < 0.0001), whereas the anisotropic longitudinal modulus polarized parallel to the CSTs showed no significant differences. Conclusion The results of this study suggest a relatively high sensitivity of two anisotropic shear moduli as noninvasive metrics for the assessment of neuronal degeneration within the CSTs. Magn Reson Med 72:1755–1761, 2014. © 2013 Wiley Periodicals, Inc.