Premium
Magnetization transfer in lamellar liquid crystals
Author(s) -
Malyarenko Dariya I.,
Zimmermann Ellen M.,
Adler Jeremy,
Swanson Scott D.
Publication year - 2014
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25034
Subject(s) - magnetization , chemistry , lamellar structure , magnetization transfer , analytical chemistry (journal) , proton , crystallography , chromatography , magnetic field , medicine , physics , quantum mechanics , magnetic resonance imaging , radiology
Purpose This study examines the relationship between quantitative magnetization transfer (qMT) parameters and the molecular composition of a model lamellar liquid crystal (LLC) system composed of 1‐decyl alcohol (decanol), sodium dodecyl sulfate (SDS), and water. Methods Samples were made within a stable lamellar mesophase to provide different ratios of total semisolid protons (SDS + decanol) to water protons. Data were collected as a function of radiofrequency power, frequency offset, and temperature. qMT parameters were estimated by fitting a standard model to the data. Fitting results of four different semisolid line shapes were compared. Results A super‐Lorentzian line shape for the semisolid component provided the best fit. The estimated amount of semisolids was proportional to the ratio of decanol‐to‐water protons. Other qMT parameters exhibited nonlinear dependence on sample composition. Magnetization transfer ratio (MTR) was a linear function of the semisolid fraction over a limited range of decanol concentration. Conclusion In LLC samples, MT between semisolid and water originates from intramolecular nOe among decanol aliphatic chain protons followed by proton exchange between decanol hydroxyl and water. Exchange kinetics is influenced by SDS, although SDS protons do not participate in MT. These studies provide clinically relevant range of semisolid fraction proportional to detected MTR. Magn Reson Med 72:1427–1434, 2014. © 2013 Wiley Periodicals, Inc.