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Correlation of MR elastography with morphometric quantification of liver fibrosis (Fibro‐C‐Index) in chronic hepatitis B
Author(s) -
Venkatesh Sudhakar K.,
Xu Shuoyu,
Tai Dean,
Yu Hanry,
Wee Aileen
Publication year - 2014
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.25002
Subject(s) - medicine , fibrosis , cirrhosis , liver biopsy , elastography , receiver operating characteristic , confidence interval , chronic hepatitis , liver fibrosis , gastroenterology , biopsy , nuclear medicine , pathology , radiology , ultrasound , virus , virology
Purpose We evaluated the correlation of MR Elastography (MRE) with morphometric assessment of liver fibrosis in chronic hepatitis B (CHB). Methods Thirty‐two patients with CHB underwent both MRE and a liver biopsy within a 6‐month interval. MRE was performed using standard MRE sequence on a 1.5 Tesla clinical scanner. The liver stiffness (LS) was measured on automatically generated stiffness maps. Morphometric quantification of fibrosis of liver biopsies was performed using a semi‐automated image analysis program and expressed as percentage area (Fibro‐C‐Index). Correlations between MRE, Fibro‐C‐Index, and histologic fibrosis stages were evaluated. Receiver operating curve (ROC) analysis of MRE and Fibro‐C‐index for differentiating fibrosis (≥F1), significant fibrosis (≥F2), advanced fibrosis (≥F3), and cirrhosis (F4) was performed. Results MRE showed excellent correlation with both Fibro‐C‐Index (r = 0.78, 95% confidence interval [CI], 0.59–0.88, P < 0.001) and histologic staging (rho = 0.87, 95% CI, 0.72–0.94, P < 0.0001). Significant differences in MRE ( P = 0.0001) and Fibro‐C‐Index ( P = 0.003) among different stages of liver fibrosis was found. MRE and Fibro‐C‐Index had similar accuracies for differentiating fibrosis stages: ≥F1 (0.87 versus 0.81, P = 0.6), ≥F2 (0.95 versus 0.94, P = 0.78), ≥F3 (0.98 versus 0.96, P = 0.76), and F4 (1.00 versus 0.92, P = 0.10). Conclusion MRE is an excellent noninvasive indicator of liver fibrosis burden in CHB. Magn Reson Med 72:1123–1129, 2014. © 2013 Wiley Periodicals, Inc.