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Time‐Resolved Angiography using InfLow Subtraction (TRAILS)
Author(s) -
Kopeinigg Daniel,
Bammer Roland
Publication year - 2014
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24985
Subject(s) - inflow , angiography , digital subtraction angiography , temporal resolution , subtraction , computer science , cardiac cycle , radiology , medicine , nuclear medicine , geology , mathematics , cardiology , physics , optics , arithmetic , oceanography
Purpose A novel pseudo‐continuous arterial spin labeling based angiographic method called Time‐Resolved Angiography using InfLow Subtraction is introduced and used to acquire time‐resolved whole‐head angiographic data sets in healthy volunteers in a clinical feasible scan time of less than 5 min. Methods Using this new method, in conjunction with a sliding window reconstruction, a temporal resolution of 7.2 ms with a low temporal footprint of 432 ms can be achieved. Results Excellent vessel delineation compared to a time‐of‐flight MRA was demonstrated. Normal variations of the vascular system including the Circle of Willis (CoW) were identified using Time‐Resolved Angiography Using Inflow Subtraction. Signal intensities were measured in various vascular segments to quantify the blood transit time. Conclusion In this feasibility study, we showed that Time‐Resolved Angiography using InfLow Subtraction can be used to acquire hemodynamic information of the whole head in healthy volunteers with a high temporal and spatial resolution. Further studies in patients that suffer from vascular diseases to explore various flow patterns including longer transit time are needed. Magn Reson Med 72:669–678, 2014. © 2013 Wiley Periodicals, Inc.