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3D late gadolinium enhancement in a single prolonged breath‐hold using supplemental oxygenation and hyperventilation
Author(s) -
Roujol Sébastien,
Basha Tamer A.,
Akçakaya Mehmet,
Foppa Murilo,
Chan Raymond H.,
Kissinger Kraig V.,
Goddu Beth,
Berg Sophie,
Manning Warren J.,
Nezafat Reza
Publication year - 2014
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24969
Subject(s) - hyperventilation , medicine , diaphragmatic breathing , oxygenation , cardiology , breathing , nuclear medicine , anesthesia , pathology , alternative medicine
Purpose To evaluate the feasibility of three‐dimensional (3D) single breath‐hold late gadolinium enhancement (LGE) of the left ventricle (LV) using supplemental oxygen and hyperventilation and compressed‐sensing acceleration. Methods Breath‐hold metrics [breath‐hold duration, diaphragmatic/LV position drift, and maximum variation of R wave to R wave (RR) interval] without and with supplemental oxygen and hyperventilation were assessed in healthy adult subjects using a real‐time single shot acquisition. Ten healthy subjects and 13 patients then underwent assessment of the proposed 3D breath‐hold LGE acquisition (field of view = 320 × 320 × 100 mm 3 , resolution = 1.6 × 1.6 × 5.0 mm 3 , acceleration rate of 4) and a free‐breathing acquisition with right hemidiaphragm navigator (NAV) respiratory gating. Semiquantitative grading of overall image quality, motion artifact, myocardial nulling, and diagnostic value was performed by consensus of two blinded observers. Results Supplemental oxygenation and hyperventilation increased the breath‐hold duration (35 ± 11 s to 58 ± 21 s; P < 0.0125) without significant impact on diaphragmatic/LV position drift or maximum variation of RR interval (both P > 0.01). LGE images were of similar quality when compared with free‐breathing acquisitions, but with reduced total scan time (85 ± 22 s to 35 ± 6 s; P < 0.001). Conclusions Supplemental oxygenation and hyperventilation allow for prolonged breath‐holding and enable single breath‐hold 3D accelerated LGE with similar image quality as free breathing with NAV. Magn Reson Med 72:850–857, 2014. © 2013 Wiley Periodicals, Inc.