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Flow compensated quantitative susceptibility mapping for venous oxygenation imaging
Author(s) -
Xu Bo,
Liu Tian,
Spincemaille Pascal,
Prince Martin,
Wang Yi
Publication year - 2014
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24937
Subject(s) - quantitative susceptibility mapping , imaging phantom , biomedical engineering , blood flow , saturation (graph theory) , nuclear magnetic resonance , cerebral veins , susceptibility weighted imaging , materials science , magnetic resonance imaging , physics , mathematics , medicine , radiology , optics , combinatorics
Purpose Venous blood oxygen saturation is an indicator of brain oxygen consumption and can be measured directly from quantitative susceptibility mapping (QSM) by deconvolving the MR phase signal. However, accurate estimation of the susceptibility of blood may be affected by flow induced phase in the presence of imaging gradient and the inhomogeneous susceptibility field gradient. The purpose of this study is to correct the flow induced error in QSM for improved venous oxygenation quantification. Methods Flow compensation is proposed for QSM by using a fully flow compensated multi‐echo gradient echo sequence for data acquisition. A quadratic fit of the phase with respect to echo time is employed for the flow phase in the presence of inhomogeneity field gradients. Phantom and in vivo experiments were carried out to validate the proposed method. Results Phantom experiments demonstrated reduced error in the estimated field map and susceptibility map. Initial data in in vivo human imaging demonstrated improvements in the quantitative susceptibility map and in the estimated venous oxygen saturation values. Conclusion Flow compensated multi‐echo acquisition and an adaptive‐quadratic fit of the phase images improves the quantitative susceptibility map of blood flow. The improved vein susceptibility enables in vivo measurement of venous oxygen saturation throughout the brain. Magn Reson Med 72:438–445, 2014. © 2013 Wiley Periodicals, Inc.