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Correlations of noninvasive BOLD and TOLD MRI with pO 2 and relevance to tumor radiation response
Author(s) -
Hallac Rami R.,
Zhou Heling,
Pidikiti Rajesh,
Song Kwang,
Stojadinovic Strahinja,
Zhao Dawen,
Solberg Timothy,
Peschke Peter,
Mason Ralph P.
Publication year - 2014
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24846
Subject(s) - carbogen , oxygenation , hyperoxia , nuclear medicine , oxygen , breathing , medicine , magnetic resonance imaging , irradiation , chemistry , lung , anesthesia , radiology , physics , organic chemistry , nuclear physics
Purpose To examine the potential use of blood oxygenation level dependent (BOLD) and tissue oxygenation level dependent (TOLD) contrast MRI to assess tumor oxygenation and predict radiation response. Methods BOLD and TOLD MRI were performed on Dunning R3327‐AT1 rat prostate tumors during hyperoxic gas breathing challenge at 4.7 T. Animals were divided into two groups. In Group 1 ( n = 9), subsequent 19 F MRI based on spin lattice relaxation of hexafluorobenzene reporter molecule provided quantitative oximetry for comparison. For Group 2 rats ( n = 13) growth delay following a single dose of 30 Gy was compared with preirradiation BOLD and TOLD assessments. Results Oxygen (100%O 2 ) and carbogen (95%O 2 /5%CO 2 ) challenge elicited similar BOLD, TOLD and pO 2 responses. Strong correlations were observed between BOLD orR 2 *response and quantitative 19 F pO 2 measurements. TOLD response showed a general trend with weaker correlation. Irradiation caused a significant tumor growth delay and tumors with larger changes in TOLD and R 1 values upon oxygen breathing exhibited significantly increased tumor growth delay. Conclusion These results provide further insight into the relationships between oxygen sensitive (BOLD/TOLD) MRI and tumor pO 2 . Moreover, a larger increase in R 1 response to hyperoxic gas challenge coincided with greater tumor growth delay following irradiation. Magn Reson Med 71:1863–1873, 2014. © 2013 Wiley Periodicals, Inc.