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Quantitative liver 31 P magnetic resonance spectroscopy at 3T on a clinical scanner
Author(s) -
Laufs Alessandra,
Livingstone Roshan,
Nowotny Bettina,
Nowotny Peter,
Wickrath Frithjof,
Giani Guido,
Bunke Jürgen,
Roden Michael,
Hwang JongHee
Publication year - 2014
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24835
Subject(s) - reproducibility , magnetic resonance imaging , nuclear medicine , chemistry , nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , proton magnetic resonance , scanner , spectroscopy , medicine , radiology , chromatography , physics , quantum mechanics , optics
Purpose The aims of this study were (i) to establish a robust and fast method to quantify hepatocellular phosphorus compounds in molar concentration on a 3T clinical scanner, (ii) to evaluate its reproducibility, and (iii) to test its feasibility for a use in large cohort studies. Method Proton‐decoupled 31 P magnetic resonance spectroscopy of liver 31 P compounds were acquired on 85 healthy subjects employing image selected in‐vivo spectroscopy localization in 13 min of acquisition at 3T. Absolute quantification was achieved using an external reference and double‐matching phantoms (inorganic phosphates and adenosine triphosphate (ATP) solutions). Reproducibility of the method was also examined. Results This method showed a high intra‐ and interday as well as inter‐ and intraobserver reproducibility ( r > 0.98; P < 0.001), with a high signal to noise ratio (SNR) (i.e., mean SNR of γ‐ATP: 16). The mean liver concentrations of 85 healthy subjects were assessed to be 1.99 ± 0.51 and 2.74 ± 0.55 mmol/l of wet tissue volume for P i and γ‐ATP, respectively. Conclusion This method reliably quantified molar concentrations of liver 31 P compounds on 85 subjects with a short total examination time (∼25 min) on a 3T clinical scanner. Thus, the current method can be readily utilized for a clinical study, such as a large cohort study. Magn Reson Med 71:1670–1675, 2014. © 2013 Wiley Periodicals, Inc.