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Tumor perfusion‐related parameter of diffusion‐weighted magnetic resonance imaging: Correlation with histological microvessel density
Author(s) -
Lee HyeJeong,
Rha Sun Young,
Chung Yong Eun,
Shim Hyo Sub,
Kim Young Jin,
Hur Jin,
Hong Yoo Jin,
Choi Byoung Wook
Publication year - 2014
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24810
Subject(s) - intravoxel incoherent motion , nuclear medicine , spearman's rank correlation coefficient , perfusion , magnetic resonance imaging , diffusion mri , effective diffusion coefficient , nuclear magnetic resonance , correlation , medicine , rank correlation , microvessel , pathology , physics , mathematics , radiology , immunohistochemistry , statistics , geometry
Purpose We obtained intravoxel incoherent motion (IVIM) parameters through biexponential analysis on diffusion‐weighted MR imaging (DWI) using multiple b values. Correlation was evaluated between these parameters and histological microvessel density (MVD) for the possibility of noninvasive evaluation of MVD with DWI. Methods Twenty‐five nude mice with the HT29 colorectal cancer cells implanted were analyzed after undergoing DWI with multiple b values (0, 50, 100, 300, 500, 700, and 1000 s/mm 2 ). Tissue diffusivity ( D t ), pseudo‐diffusion coefficient ( D p ), and perfusion fraction ( f p ) were calculated using a biexponential analysis, and these parameters were correlated with MVD. The MVD was determined with the CD31 stain. For statistical analysis, Spearman's rank correlation was applied. Results The mean value and correlation coefficient with MVD for each IVIM parameter were as follows: D t = 0.98 ± 0.06 × 10 −3 mm 2 /s with r = 0.139 ( P = 0.508); D p = 23.70 ± 7.94 × 10 −3 mm 2 /s with r = 0.782 ( P < 0.001); and f p = 15.58 ± 5.7% with r = 0.749 ( P < 0.001). D p and f p showed significant correlation with MVD, but D t did not. Conclusion The IVIM parameters, D p and f p , on DWI might be used in the noninvasive evaluation of MVD. Magn Reson Med 71:1554–1558, 2014. © 2013 Wiley Periodicals, Inc .