Adiabatic inversion pulses for myocardial T1 mapping

Purpose To evaluate the error in T1 estimates using inversion‐recovery‐based T1 mapping due to imperfect inversion and to perform a systematic study of adiabatic inversion pulse designs in order to maximize inversion efficiency for values of transverse relaxation (T2) in the myocardium subject to a peak power constraint. Methods The inversion factor for hyperbolic secant and tangent/hyperbolic tangent adiabatic full passage waveforms was calculated using Bloch equations. A brute‐force search was conducted for design parameters: pulse duration, frequency range, shape parameters, and peak amplitude. A design was selected that maximized the inversion factor over a specified range of amplitude and off‐resonance and validated using phantom measurements. Empirical correction for imperfect inversion was performed. Results The tangent/hyperbolic tangent adiabatic pulse was found to outperform hyperbolic secant designs and achieve an inversion factor of 0.96 within ±150 Hz over 25% amplitude range with 14.7 µT peak amplitude. T1 mapping errors of the selected design due to imperfect inversion was ∼4% and could be corrected to <1%. Conclusions Nonideal inversion leads to significant errors in inversion‐recovery‐based T1 mapping. The inversion efficiency of adiabatic pulses is sensitive to transverse relaxation. The tangent/hyperbolic tangent design achieved the best performance subject to the peak amplitude constraint. Magn Reson Med 71:1428–1434, 2014. © 2013 Wiley Periodicals, Inc .