Premium
Chemical exchange saturation transfer effect in blood
Author(s) -
Zheng Shaokuan,
van der Bom Imramsjah M. J.,
Zu Zhongliang,
Lin Guoxing,
Zhao Yansong,
Gounis Matthew J.
Publication year - 2014
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24770
Subject(s) - magnetization transfer , in vivo , nuclear magnetic resonance , ex vivo , chemistry , magnetic resonance imaging , blood vessel , nuclear medicine , biomedical engineering , medicine , radiology , biology , physics , microbiology and biotechnology
Purpose In this report, the feasibility of using blood as an agent for Chemical Exchange Saturation Transfer (CEST) effect is investigated. Methods The CEST effect of porcine blood samples was investigated on a 3.0 T MRI scanner using various power levels and on a 14.1 T NMR spectrometer. As a proof‐of‐concept that CEST can be used to image blood in vivo, the technique was applied in two locations of healthy human volunteers, namely, the femoral artery and the M1‐segment of the middle cerebral artery. Results The blood sample experiments showed that maximum CEST Magnetization Transfer Ratio asymmetry (MTR asym ) values of ∼ 12% were achieved, with likely contributions from multiple blood components. These findings were confirmed during the in vivo experiments where CEST signal of blood was clearly greater than surrounding muscular (2%) and brain tissue (3%). Conclusion Ex vivo and in vivo results show that blood is a suitable CEST agent that generates sufficient CEST contrast relative to surrounding tissue. Magn Reson Med 71:1082–1092, 2014. © 2013 Wiley Periodicals, Inc.