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Ultrashort echo time bi‐component analysis of cortical bone—a field dependence study
Author(s) -
Li Shihong,
Chang Eric Y.,
Bae Won C.,
Chung Christine B.,
Gao Song,
Bao Shanglian,
Bydder Graeme M.,
Hua Yanqing,
Du Jiang
Publication year - 2014
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24769
Subject(s) - cortical bone , bound water , echo time , chemistry , field strength , nuclear magnetic resonance , free water , anatomy , physics , magnetic resonance imaging , biology , medicine , molecule , magnetic field , organic chemistry , radiology , quantum mechanics , environmental engineering , engineering
Purpose The purpose of this study is to investigate the effect of differing field strength on theT 2 *of cortical bone at 1.5 T and 3 T. Methods Ultrashort echo time pulse sequences were used to study six bovine and nine human bone samples at 1.5 T and 3 T using single‐ and bi‐componentT 2 *analysis. Results On average, the bound waterT 2 *of bovine bone decreased by 16% (from 0.32 ms at 1.5 T to 0.27 ms at 3 T, P < 0.01) and the bound waterT 2 *of human bone decreased by 21% (from 0.42 ms at 1.5 T to 0.33 ms at 3 T, P < 0.01) at the higher field strength. The free waterT 2 *of bovine bone decreased by 50% (from 4.23 ms at 1.5 T to 2.12 ms at 3 T, P < 0.001) and the free waterT 2 *of human bone decreased by 68% (from 7.65 ms at 1.5 T to 2.46 ms at 3 T, P < 0.001) at the higher field strength. Bound and free water fractions showed only minor change with field strength in bovine (< 2%, P > 0.05) and human bone (< 4%, P > 0.05). Conclusion Ultrashort echo time bi‐component analysis provides consistent bound and free water fractions at 1.5 T and 3 T, thereby allowing field‐independent comparisons. Magn Reson Med 71:1075–1081, 2014. © 2013 Wiley Periodicals, Inc.