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Simultaneous imaging of in vivo conductivity and susceptibility
Author(s) -
Kim DongHyun,
Choi Narae,
Gho SungMin,
Shin Jaewook,
Liu Chunlei
Publication year - 2014
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24759
Subject(s) - imaging phantom , quantitative susceptibility mapping , conductivity , phase (matter) , nuclear magnetic resonance , magnetic susceptibility , signal (programming language) , materials science , magnetic resonance imaging , image quality , noise (video) , physics , computer science , image (mathematics) , optics , artificial intelligence , radiology , condensed matter physics , medicine , quantum mechanics , programming language
Purpose Approaches for quantitative mapping of electric conductivity and magnetic susceptibility using MRI have been developed independently. The purpose of this study is to present a method to simultaneously acquire information on conductivity and susceptibility and to produce images based on these properties. Methods A 3D multiecho gradient‐echo sequence was used. Phase evolution during the multiecho was used to produce quantitative susceptibility maps, while the phase value at zero echo time was retrieved, and used to generates quantitative conductivity maps. Electromagnetic simulations were performed to evaluate the phase distribution due to conductivity variations. Phantom and in vivo data were also acquired to assess the quality of images produced. Results Simulations demonstrated that phase differences across objects increase s with size and conductivity. For an accurate conductivity estimate, the maximum echo time was approximately equal to the trueT 2 *value in order to achieve signal‐to‐noise ratio maximization. The most accurate susceptibility was obtained when separating phase contribution from conductivity. Phantom and in vivo results showed good quality images representing the electromagnetic properties. Conclusion A simultaneous quantitative electromagnetic property imaging approach is demonstrated here. The approach not only improves the efficiency of mapping electromagnetic properties, but can also improve the accuracy of susceptibility mapping by separating image phases introduced by conductivity and susceptibility. Magn Reson Med 71:1144–1150, 2014. © 2013 Wiley Periodicals, Inc.