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Ultrafast localized two‐dimensional magnetic resonance correlated spectroscopy via spatially encoded technique
Author(s) -
Lin Yanqin,
Zhang Qinta,
Wei Zhiliang,
Cai Shuhui,
Zhong Jianhui,
Chen Zhong
Publication year - 2014
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24731
Subject(s) - imaging phantom , spectroscopy , ultrashort pulse , nuclear magnetic resonance , pulse sequence , nuclear magnetic resonance spectroscopy , chemistry , limiting , pulse (music) , signal (programming language) , two dimensional nuclear magnetic resonance spectroscopy , physics , optics , computer science , laser , mechanical engineering , quantum mechanics , detector , programming language , engineering
Purpose To speed up acquisition of localized two‐dimensional (2D) correlated spectroscopy (LCOSY). Methods A new pulse sequence, dubbed as spatially encoded localized COSY (SLCOSY), based on spatially encoded technique, was developed for localized 2D correlated spectroscopy. It can be used to collect a full 2D spectrum in a single scan and thus on a subsecond timescale. Results SLCOSY spectrum of a two‐compartment phantom was obtained with a total acquisition time of 773 ms, with its volume localization confirmed. Localized 2D COSY spectrum of a proton magnetic resonance spectroscopy brain phantom within 12 s shows the ability of SLCOSY to detect the metabolites at physiological concentrations. All 10 constituent metabolites in this phantom are reliably detected. SLCOSY spectrum of a sample of pig brain tissue with the acquisition time of 32 s demonstrates the feasibility of SLCOSY for the detection of biological tissues. Twelve pairs of cross peaks are identified. Conclusion The new method proposed herein enables ultrafast collection of a full 2D COSY spectrum, and it can also be used for fast in vivo analysis of metabolites, when signal‐to‐noise ratio is not a limiting factor. Magn Reson Med 71:903–910, 2014. © 2013 Wiley Periodicals, Inc.