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Noncontrast skeletal muscle oximetry
Author(s) -
Zheng Jie,
An Hongyu,
Coggan Andrew R.,
Zhang Xiaodong,
Bashir Adil,
Muccigrosso David,
Peterson Linda R.,
Gropler Robert J.
Publication year - 2014
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24669
Subject(s) - skeletal muscle , isometric exercise , perfusion , oxygenation , medicine , calf muscle , cardiology , soleus muscle , nuclear medicine , chemistry
Purpose The objective of this study was to develop a new noncontrast method to directly quantify regional skeletal muscle oxygenation. Methods The feasibility of the method was examined in five healthy volunteers using a 3 T clinical MRI scanner, at rest and during a sustained isometric contraction. The perfusion of skeletal muscle of the calf was measured using an arterial spin labeling method, whereas the oxygen extraction fraction of the muscle was measured using a susceptibility‐based MRI technique. Results In all volunteers, the perfusion in soleus muscle increased significantly from 6.5 ± 2.0 mL (100 g min) −1 at rest to 47.9 ± 7.7 mL (100 g min) −1 during exercise ( P < 0.05). Although the corresponding oxygen extraction fraction did not change significantly, the rate of oxygen consumption increased from 0.43 ± 0.13 to 4.2 ± 1.5 mL (100 g min) −1 ( P < 0.05). Similar results were observed in gastrocnemius muscle but with greater oxygen extraction fraction increase than the soleus muscle. Conclusion This is the first MR oximetry developed for quantification of regional skeletal muscle oxygenation. A broad range of medical conditions could benefit from these techniques, including cardiology, gerontology, kinesiology, and physical therapy. Magn Reson Med 71:318–325, 2014. © 2013 Wiley Periodicals, Inc.