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Rapid measurement of arterial input function in mouse tail from projection phases
Author(s) -
Moroz Jennifer,
Wong Clayton L.,
Yung Andrew C.,
Kozlowski Piotr,
Reinsberg Stefan A.
Publication year - 2014
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24660
Subject(s) - projection (relational algebra) , function (biology) , nuclear magnetic resonance , physics , chemistry , biomedical engineering , mathematics , medicine , biology , algorithm , evolutionary biology
Purpose To measure the arterial input function (AIF) in a mouse tail at high temporal resolution with signal phase of MR projections. Methods The technique involves the acquisition of one 2D image before injection, followed by a series of projections before, during, and after contrast injection. Differences in the signal phase, relative to the mean preinjection phase, were calculated and converted into a concentration of Gd. Results An AIF with a temporal resolution of 100 ms was measured and verified with colorimetry (in a flow phantom) and mass spectrometry analysis (in vivo). The projection‐based AIF is expected to better represent the rapid contrast kinetics in the blood following injection, thus improving the accuracy of quantitative dynamic contrast‐enhanced‐MRI analysis. Colorimetry experiments confirmed that signal phase is preferred over magnitude for a precise determination of an AIF. In‐vivo experiments demonstrate the feasibility of our approach in mice. Conclusion AIFs can be measured quickly and precisely using phase from projections. Phase data are sensitive to the flow velocity; but this sensitivity is significantly reduced when flow compensation was used. Magn Reson Med 71:238–245, 2014. © 2013 Wiley Periodicals, Inc.