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Induced clustered nanoconfinement of superparamagnetic iron oxide in biodegradable nanoparticles enhances transverse relaxivity for targeted theranostics
Author(s) -
Ragheb Ragy R. T.,
Kim Dongin,
Bandyopadhyay Arunima,
Chahboune Halima,
Bulutoglu Beyza,
Ezaldein Harib,
Criscione Jason M.,
Fahmy Tarek M.
Publication year - 2013
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24622
Subject(s) - superparamagnetism , nanoparticle , iron oxide nanoparticles , drug delivery , iron oxide , targeted drug delivery , materials science , nanotechnology , chemistry , plga , organic chemistry , magnetization , physics , quantum mechanics , magnetic field
Purpose Combined therapeutic and diagnostic agents, “theranostics” are emerging valuable tools for noninvasive imaging and drug delivery. Here, we report on a solid biodegradable multifunctional nanoparticle that combines both features. Methods Poly(lactide‐ co ‐glycolide) nanoparticles were engineered to confine superparamagnetic iron oxide contrast for magnetic resonance imaging while enabling controlled drug delivery and targeting to specific cells. To achieve this dual modality, fatty acids were used as anchors for surface ligands and for encapsulated iron oxide in the polymer matrix. Results We demonstrate that fatty acid modified iron oxide prolonged retention of the contrast agent in the polymer matrix during degradative release of drug. Antibody‐fatty acid surface modification facilitated cellular targeting and subsequent internalization in cells while inducing clustering of encapsulated fatty‐acid modified superparamagnetic iron oxide during particle formulation. This induced clustered confinement led to an aggregation within the nanoparticle and, hence, higher transverse relaxivity, r 2 , (294 mM −1 s −1 ) compared with nanoparticles without fatty‐acid ligands (160 mM −1 s −1 ) and higher than commercially available superparamagnetic iron oxide nanoparticles (89 mM −1 s −1 ). Conclusion Clustering of superparamagnetic iron oxide in poly(lactide‐ co ‐glycolide) did not affect the controlled release of encapsulated drugs such as methotrexate or clodronate and their subsequent pharmacological activity, thus highlighting the full theranostic capability of our system. Magn Reson Med 70:1748–1760, 2013. © 2013 Wiley Periodicals, Inc.