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Partial volume correction in arterial spin labeling using a Look‐Locker sequence
Author(s) -
Petr Jan,
Schramm Georg,
Hofheinz Frank,
Langner Jens,
den Hoff Jörg
Publication year - 2013
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24601
Subject(s) - segmentation , artificial intelligence , image resolution , volume (thermodynamics) , resolution (logic) , arterial spin labeling , linear regression , partial volume , computer science , nuclear medicine , high resolution , pattern recognition (psychology) , computer vision , nuclear magnetic resonance , magnetic resonance imaging , mathematics , medicine , physics , statistics , radiology , geology , remote sensing , quantum mechanics
Purpose Partial volume (PV) effects are caused by limited spatial resolution and significantly affect cerebral blood flow investigations with arterial spin labeling. Therefore, accurate PV correction (PVC) procedures are required. PVC is commonly based on PV maps obtained from segmented high‐resolution T 1 ‐weighted images. Segmentation of these images is error‐prone, and it can be difficult to coregister these images accurately with the single‐shot ASL images such as those created by echo‐planar imaging (EPI). In this paper, an alternative method for PV map generation is proposed. Methods The Look‐Locker EPI (LL‐EPI) acquisition is used for analyzing the T 1 ‐recovery curve and for subsequent PV map generation. The new method was evaluated in five healthy volunteers (mean age 30 ± 3.7 years). Results By applying a linear regression method for PVC, a 12% decrease in regression error was reached with the new method. Conclusion PV maps extraction from LL‐EPI is a viable, possibly superior alternative to the standard approach based on segmentation of high‐resolution T 1 ‐weighted images. Magn Reson Med 70:1535–1543, 2013. © 2012 Wiley Periodicals, Inc.