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NMR‐based diffusion pore imaging by double wave vector measurements
Author(s) -
Kuder Tristan Anselm,
Laun Frederik Bernd
Publication year - 2013
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24515
Subject(s) - diffusion , nuclear magnetic resonance , relaxation (psychology) , signal (programming language) , sequence (biology) , pulsed field gradient , a priori and a posteriori , diffusion mri , convergence (economics) , free induction decay , work (physics) , resolution (logic) , chemistry , physics , biological system , materials science , magnetic resonance imaging , computer science , spin echo , thermodynamics , artificial intelligence , philosophy , economic growth , psychology , social psychology , biochemistry , epistemology , radiology , programming language , medicine , economics , biology
One main interest of nuclear magnetic resonance (NMR) diffusion experiments is the investigation of boundaries such as cell membranes hindering the diffusion process. NMR diffusion measurements allow collecting the signal from the whole sample. This mainly eliminates the problem of vanishing signal at increasing resolution. It has been a longstanding question if, in principle, the exact shape of closed pores can be determined by NMR diffusion measurements. In this work, we present a method using short diffusion gradient pulses only, which is able to reveal the shape of arbitrary closed pores without relying on a priori knowledge. In comparison to former approaches, the method has reduced demands on relaxation times due to faster convergence to the diffusion long‐time limit and allows for a more flexible NMR sequence design, because, e.g., stimulated echoes can be used. Magn Reson Med 70:836–841, 2013. © 2012 Wiley Periodicals, Inc.