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In vivo measurement of CBF using 17 O NMR signal of metabolically produced H 2 17 O as a perfusion tracer
Author(s) -
Zhu XiaoHong,
Zhang Yi,
Wiesner Hannes M.,
Ugurbil Kamil,
Chen Wei
Publication year - 2013
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24469
Subject(s) - in vivo , nuclear magnetic resonance , tracer , chemistry , perfusion , signal (programming language) , physics , radiochemistry , nuclear physics , medicine , biology , computer science , microbiology and biotechnology , cardiology , programming language
The cerebral metabolic rate of oxygen of small animals can be reliably imaged using the in vivo 17 O magnetic resonance approach at high field. However, a separate measurement is required for imaging the cerebral blood flow in the same animal. In this study, we demonstrate that the 17 O NMR signal of metabolically produced H 2 17 O in the rat brain following an 17 O 2 inhalation can serve as a perfusion tracer and its decay rate can be used to determine the absolute values of cerebral blood flow across a wide range of animal conditions. This finding suggests that the in vivo 17 O magnetic resonance approach is capable of imaging both cerebral metabolic rate of oxygen and cerebral blood flow simultaneously and noninvasively; and it provides new utilities for studying the cerebral oxygen metabolism and perfusion commonly associated with brain function and diseases. Magn Reson Med 70:309–314, 2013. © 2012 Wiley Periodicals, Inc.