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Metabolic imaging of multiple X‐nucleus resonances
Author(s) -
Steinseifer Isabell K.,
Wijnen Jannie P.,
Hamans Bob C.,
Heerschap Arend,
Scheenen Tom W. J.
Publication year - 2013
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24456
Subject(s) - phosphocreatine , flip angle , nuclear magnetic resonance , imaging phantom , excitation , chemistry , dynamic imaging , pulse (music) , dispersion (optics) , pulse sequence , magnetic resonance imaging , magnetic resonance spectroscopic imaging , physics , optics , image processing , detector , energy metabolism , computer science , medicine , quantum mechanics , digital image processing , artificial intelligence , image (mathematics) , radiology
This study describes a technique for fast imaging of x‐nuclei metabolites. Due to increased sensitivity and larger chemical shift dispersion at high magnetic fields, images of multiple metabolites can be obtained simultaneously by selective excitation of their resonances with a multifrequency selective radiofrequency pulse at any desired flip angle. This aim is achieved by combining a three‐dimensional gradient echo imaging sequence with a Shinnar‐LeRoux optimized excitation pulse. A proper choice of bandwidth, imaging matrix size, and field of view allows using the chemical shift dispersion of the different resonances to completely separate their images within one large field of view. The method of fast metabolic imaging is illustrated with 13 C measurements of a phantom containing a solution of 13 C labeled glucose, lactate, and sodium octanoate and by dynamic measurements of the 31 P metabolites phosphocreatine and β‐adenosine triphosphate in human femoral muscle in vivo, both at 7T. With dynamic selective 31 P imaging of the larger part of the upper leg, phosphocreatine signal intensity changes of specific muscles can be studied simultaneously by analyzing the sum of phosphocreatine signals within arbitrarily shaped regions of interest following the muscles' contours. This concept of dynamic metabolic imaging can be applied to other organs and further expanded to other MR‐detectable nuclei and metabolites. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.