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Simultaneous single‐quantum and triple‐quantum‐filtered MRI of 23Na (SISTINA)
Author(s) -
Fiege Daniel P.,
Romanzetti Sandro,
Mirkes Christian C.,
Brenner Daniel,
Shah N. Jon
Publication year - 2013
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24417
Subject(s) - quantum , nuclear magnetic resonance , physics , projection (relational algebra) , computer science , pulse sequence , nuclear medicine , algorithm , medicine , quantum mechanics
The low MR sensitivity of the sodium nucleus and its low concentration in the human body constrain acquisition time. The use of both single‐quantum and triple‐quantum sodium imaging is, therefore, restricted. In this work, we present a novel MRI sequence that interleaves an ultra‐short echo time radial projection readout into the three‐pulse triple‐quantum preparation. This allows for simultaneous acquisition of tissue sodium concentration weighted as well as triple‐quantum filtered images. Performance of the sequence is shown on phantoms. The method is demonstrated on six healthy informed volunteers and is applied to three cases of brain tumors. A comparison with images from tumor specific O‐(2‐[18F]fluoroethyl)‐ L ‐tyrosine positron emission tomography and standard MR images is presented. The combined information of the triple‐quantum‐filtered images with single‐quantum images may enable a better understanding of tissue viability. Future studies can benefit from the evaluation of both contrasts with shortened acquisition times. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.