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Monte Carlo simulations of Donnan equilibrium in cartilage
Author(s) -
Algotsson Jenny,
Åkesson Torbjörn,
Forsman Jan
Publication year - 2012
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24409
Subject(s) - monte carlo method , magnetic resonance imaging , cartilage , nuclear magnetic resonance , resonance (particle physics) , ion , gadolinium , chemistry , physics , atomic physics , medicine , anatomy , radiology , mathematics , statistics , organic chemistry
23 Na magnetic resonance imaging and the delayed gadolinium‐enhanced magnetic resonance imaging methods to investigate cartilage can be used to determine the fixed charge density of cartilage. The methods give results that differ by a factor of 2. In this study, we use Monte Carlo simulations on a model system of cartilage and find that the difference originates from the Coulombic intermolecular interactions between the ions in the cartilage, and in the synovial fluid. Those interactions are neglected in the standard Donnan analysis that generally is adopted to evaluate magnetic resonance imaging data. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc.