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An optimized velocity selective arterial spin labeling module with reduced eddy current sensitivity for improved perfusion quantification
Author(s) -
Meakin James A.,
Jezzard Peter
Publication year - 2012
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24302
Subject(s) - eddy current , perfusion , arterial spin labeling , sensitivity (control systems) , nuclear magnetic resonance , rotation (mathematics) , biomedical engineering , chemistry , perfusion scanning , physics , medicine , computer science , cardiology , electronic engineering , quantum mechanics , artificial intelligence , engineering
Abstract Velocity‐selective (VS) arterial spin labeling is a promising method for measuring perfusion in areas of slow or collateral flow by eliminating the bolus arrival delay associated with other spin labeling techniques. However, B 0 and B 1 inhomogeneities and eddy currents during the VS preparation hinder accurate quantification of perfusion with VS arterial spin labeling. In this study, it is demonstrated through simulations and experiments in healthy volunteers that eddy currents cause erroneous tagging of static tissue. Consequently, mean gray matter perfusion is overestimated by up to a factor of 2, depending on the VS preparation used. A novel eight‐segment B 1 insensitive rotation VS preparation is proposed to reduce eddy current effects while maintaining the B 0 and B 1 insensitivity of previous preparations. Compared to two previous VS preparations, the eight‐segment B 1 insensitive rotation is the most robust to eddy currents and should improve the quality and reliability of VS arterial spin labeling measurements in future studies. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.