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Spectrally selective 3D TSE imaging of phosphocreatine in the human calf muscle at 3 T
Author(s) -
Parasoglou Prodromos,
Xia Ding,
Regatte Ravinder R.
Publication year - 2012
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24288
Subject(s) - phosphocreatine , nuclear magnetic resonance , flip angle , image resolution , voxel , calf muscle , magnetic resonance imaging , chemistry , signal to noise ratio (imaging) , physics , optics , medicine , radiology , energy metabolism , surgery
Quantitative information about concentrations of several metabolites in human skeletal muscle can be obtained through localized 31 P magnetic resonance spectroscopy methods. However, these methods have shortcomings: long acquisition times, limited volume coverage, and coarse resolution. Significantly higher spatial and temporal resolution of imaging of single metabolites can be achieved through spectrally selective three‐dimensional imaging methods. This study reports the implementation of a three‐dimensional spectrally selective turbo spin‐echo sequence, on a 3T clinical system, to map the concentration of phosphocreatine in the human calf muscle with significantly increased spatial resolution and in a clinically feasible scan time. Absolute phosphocreatine quantification was performed with the use of external phantoms after relaxation and flip angle correction of the turbo spin‐echo voxel signal. The mean ± standard deviation of the phosphocreatine concentration measured in five healthy volunteers was 29.4 ± 2.5 mM with signal‐to‐noise ratio of 14:1 and voxel size of 0.52 mL. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.