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Selective homonuclear polarization transfer for spectroscopic imaging of GABA at 7T
Author(s) -
Pan J. W.,
Duckrow R. B.,
Spencer D. D.,
Avdievich N. I.,
Hetherington H. P.
Publication year - 2013
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24283
Subject(s) - homonuclear molecule , nuclear magnetic resonance , epilepsy , chemistry , magnetic resonance imaging , pulse sequence , neuroscience , physics , medicine , biology , molecule , radiology , organic chemistry
We develop and implement a selective homonuclear polarization transfer method for the detection of 3.0 ppm C‐4 GABA resonance by spectroscopic imaging in the human brain at 7T. This single shot method is demonstrated with simulations and phantoms, which achieves comparable efficiency of detection to that of J‐difference editing. The macromolecule resonance that commonly co‐edits with GABA is suppressed at 7T through use of a narrow band preacquisition suppression pulse. This technique is implemented in humans with an eight channel transceiver array and high degree B 0 shimming to measure supplementary motor area and thalamic GABA in controls ( n = 8) and epilepsy patients ( n = 8 total). We find that the GABA/ N ‐acetyl aspartate ratio in the thalamus of control volunteers, well controlled and poorly controlled epilepsy patients are 0.053 ± 0.012 ( n = 8), 0.090 ± 0.012 ( n = 2), and 0.038 ± 0.009 ( n = 6), respectively. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.