Premium
Transperineal prostate MR elastography: Initial in vivo results
Author(s) -
Sahebjavaher Ramin S.,
Baghani Ali,
Honarvar Mohammad,
Sinkus Ralph,
Salcudean Septimiu E.
Publication year - 2013
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24268
Subject(s) - magnetic resonance elastography , imaging phantom , elastography , magnetic resonance imaging , prostate , acoustics , computer science , biomedical engineering , physics , nuclear medicine , ultrasound , radiology , medicine , cancer
Abstract This article presents a new approach to magnetic resonance elastography of the prostate using transperineal mechanical excitation. This approach is validated using a prostate elasticity phantom and in vivo studies of healthy volunteers. It is demonstrated that the transperineal approach can generate shear wave amplitudes on the order of 6–30 μm in the mid‐gland region. The driver was implemented using an electromagnetic actuator with a hydraulic transmission system. The magnetic resonance elastography acquisition time has been reduced significantly by using a “second harmonic” approach. Displacement fields are processed using the established three‐dimensional local frequency estimation algorithm. The three‐dimensional curl‐based direct inversion was used to calculate the local wavelength. The traveling wave expansion algorithm was used to reconstruct the wave damping image for one case. Using the proposed method, it was possible to resolve lesions of 0.5 cc in the phantom study. Repeatability experiments were performed and analyzed. The results from this study indicate that transperineal magnetic resonance elastography—without an endorectal coil—is a suitable candidate for a patient study involving multiparametric magnetic resonance imaging of prostate cancer, where magnetic resonance elastography may provide additional information for improved diagnosis and image‐based surveillance. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.