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Fast metabolite mapping in the pig heart after injection of hyperpolarized 13 C‐pyruvate with low‐flip angle balanced steady‐state free precession imaging
Author(s) -
Månsson Sven,
Petersson J. Stefan,
Scheffler Klaus
Publication year - 2012
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24183
Subject(s) - flip angle , nuclear magnetic resonance , hyperpolarization (physics) , metabolite , chemistry , cardiac imaging , physics , magnetic resonance imaging , nuclear magnetic resonance spectroscopy , medicine , biochemistry , cardiology , radiology
The conversion of hyperpolarized 13 C pyruvate to metabolic products in the Krebs cycle provides valuable information about the metabolic status and the viability of the myocardium. Therefore, imaging methods must be able to spectrally discriminate different 13 C metabolites. However, the requirement for spectral selectivity conflicts with the demands for rapid image acquisition and high spatial resolution in cardiac imaging. In this work, the feasibility of a balanced steady state free precession sequence with low flip angles was investigated in the pig heart after injection of hyperpolarized 13 C 1 ‐pyruvate. Using cardiac gating, it was possible to acquire 13 C‐bicarbonate images within a single heartbeat (acquisition time 150 ms) without destroying the substrate signal from the hyperpolarized pyruvate. Therefore, the technique may be useful in dynamic studies of cardiac metabolism. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc.