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Measurements of T 1 ‐relaxation in ex vivo prostate tissue at 132 μT
Author(s) -
Busch Sarah,
Hatridge Michael,
Mößle Michael,
Myers Whittier,
Wong Travis,
Mück Michael,
Chew Kevin,
Kuchinsky Kyle,
Simko Jeffry,
Clarke John
Publication year - 2012
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24177
Subject(s) - ex vivo , prostate cancer , prostate , cancer , in vivo , nuclear medicine , image contrast , contrast (vision) , nuclear magnetic resonance , medicine , pathology , biology , physics , microbiology and biotechnology , optics
The proton T 1 was measured at 132 μT in ex vivo prostate tissue specimens from radical prostatectomies of 35 patients with prostate cancer. Each patient provided two specimens. The NMR and MRI measurements involved proton repolarization, a field of typically 150 mT and detection of the 5.6‐kHz signal with a superconducting quantum interference device. Values of T 1 varied from 41 to 86 ms. Subsequently, the percentages of tissue types were determined histologically. The theoretical image contrast is quantified for each case by δ = [1 – T 1 (more cancer)/ T 1 (less cancer)]. A linear fit of δ versus difference in percentage cancer yields T 1 (100% cancer)/ T 1 (0% cancer) = 0.70 ± 0.05 with correlation coefficient R 2 = 0.30. Two‐dimensional T 1 maps for four specimens demonstrate variation within a single specimen. These results suggest that MR images with T 1 contrast established at ultra‐low fields may discriminate prostate cancer from normal prostate tissue in vivo without a contrast agent. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc.