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T 2 prep three‐dimensional spiral imaging with efficient whole brain coverage for myelin water quantification at 1.5 tesla
Author(s) -
Nguyen Thanh D.,
Wisnieff Cynthia,
Cooper Mitchell A.,
Kumar Dushyant,
Raj Ashish,
Spincemaille Pascal,
Wang Yi,
Vartanian Tim,
Gauthier Susan A.
Publication year - 2012
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.24128
Subject(s) - relaxometry , spiral (railway) , white matter , spin echo , nuclear magnetic resonance , myelin , gradient echo , magnetic resonance imaging , physics , chemistry , nuclear medicine , medicine , mathematics , neuroscience , radiology , biology , mathematical analysis , central nervous system
Quantitative assessment of myelination is important for characterizing tissue damage and evaluating response to therapy in white matter diseases such as multiple sclerosis. Conventional multicomponent T 2 relaxometry based on the two‐dimensional (2D) multiecho spin echo sequence is a promising method to measure myelin water fraction, but its clinical utility is impeded by the prohibitively long data acquisition and limited brain coverage. The objective of this study was to develop a signal‐to‐noise ratio efficient 3D T 2 prep spiral gradient echo (3D SPIRAL) sequence for full brain T 2 relaxometry and to validate this sequence using 3D multiecho spin echo as reference standard in healthy brains at 1.5 T. 3D SPIRAL was found to provide similar myelin water fraction in six selected white and gray matter areas using region‐of‐interest signal averaging analysis ( N = 7, P > 0.05). While 3D multiecho spin echo only provided partial brain coverage, 3D SPIRAL enabled whole brain coverage with a fivefold higher acquisition speed per imaging slice and similar signal‐to‐noise ratio efficiency. Both 3D sequences provided superior signal‐to‐noise ratio efficiency when compared to the conventional 2D multiecho spin echo approach. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.