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Evaluation of combined bevacizumab plus irinotecan therapy in brain tumors using magnetic resonance imaging measures of relative cerebral blood volume
Author(s) -
Pechman Kimberly R.,
Donohoe Deborah L.,
Bedekar Devyani P.,
Kurpad Shekar N.,
Schmainda Kathleen M.
Publication year - 2012
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.23315
Subject(s) - irinotecan , bevacizumab , medicine , magnetic resonance imaging , cerebral blood volume , oncology , radiology , chemotherapy , cancer , colorectal cancer
Abstract Frequently, bevacizumab is combined with chemotherapeutics such as irinotecan, motivated by studies showing improved clinical outcomes compared with historical controls. However, no systematic studies have been performed to determine if and how these drugs should be combined for optimal therapeutic response. The purpose of this study was to characterize the temporal combinations of bevacizumab and irinotecan by measuring the contrast‐agent enhanced tumor volumes and relative cerebral blood volume using dynamic susceptibility contrast imaging. The studies, performed in the U87 brain tumor model, show a vascular normalization window with bevacizumab monotherapy and are consistent with clinical indications of no additional benefit in the addition of irinotecan to bevacizumab therapy. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.