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Chemical exchange saturation transfer magnetic resonance imaging of human knee cartilage at 3 T and 7 T
Author(s) -
Singh Anup,
Haris Mohammad,
Cai Kejia,
Kassey Victor B.,
Kogan Feliks,
Reddy Damodar,
Hariharan Hari,
Reddy Ravinder
Publication year - 2012
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.23250
Subject(s) - knee cartilage , saturation (graph theory) , nuclear magnetic resonance , magnetic resonance imaging , cartilage , magnetic field , pulse (music) , chemistry , amplitude , articular cartilage , materials science , physics , optics , osteoarthritis , anatomy , mathematics , medicine , pathology , alternative medicine , combinatorics , quantum mechanics , detector , radiology
The sensitivity of chemical exchange saturation transfer (CEST) on glycosaminoglycans (GAGs) in human knee cartilage (gagCEST) in vivo was evaluated at 3 and 7 T field strengths. Calculated gagCEST values without accounting for B 0 inhomogeneity (∼0.6 ppm) were >20%. After B 0 inhomogeneity correction, calculated gagCEST values were negligible at 3 T and ∼6% at 7 T. These results suggest that accurate B 0 correction is a prerequisite for observing reliable gagCEST. Results obtained with varying saturation pulse durations and amplitudes as well as the consistency between numerical simulations and our experimental results indicate that the negligible gagCEST observed at 3 T is due to direct saturation effects and fast exchange rate. As GAG loss from cartilage is expected to result in a further reduction in gagCEST, gagCEST method is not expected to be clinically useful at 3 T. At high fields such as 7 T, this method holds promise as a viable clinical technique. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.