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Differential effect of isoflurane, medetomidine, and urethane on BOLD responses to acute levo‐tetrahydropalmatine in the rat
Author(s) -
Liu Xiping,
Li Rupeng,
Yang Zheng,
Hudetz Anthony G.,
Li ShiJiang
Publication year - 2012
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.23243
Subject(s) - medetomidine , isoflurane , tetrahydropalmatine , anesthetic , anesthesia , pharmacology , medicine , chemistry , blood pressure , pathology , heart rate , alternative medicine , traditional chinese medicine , corydalis
Levo‐tetrahydropalmatine ( l ‐THP) has shown significant promise in preclinical and clinical studies to treat drug addiction. Pharmacological MRI methods can elucidate the regional cerebral effects of l ‐THP, but there are potential confounds from the use of general anesthesia. To investigate the possible anesthetic–drug interactions for the pharmacological MRI result of acute l ‐THP, we examined acute blood oxygen level‐dependent responses of both 5 and 20 mg/kg l ‐THP in naïve rats during general anesthesia achieved with three agents: isoflurane, medetomidine, and urethane. We found that with acute l ‐THP administration, isoflurane revealed the smallest blood oxygen level‐dependent activation areas. In addition, urethane had the most activation areas; however, they were all negative. Medetomidine showed mixed positive and negative activations. Region‐specific interactions were found between the l ‐THP‐induced blood oxygen level‐dependent responses and the anesthetic agents. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.