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IDEAL spiral CSI for dynamic metabolic MR imaging of hyperpolarized [1‐ 13 C]pyruvate
Author(s) -
Wiesinger Florian,
Weidl Eliane,
Menzel Marion I.,
Janich Martin A.,
Khegai Oleksandr,
Glaser Steffen J.,
Haase Axel,
Schwaiger Markus,
Schulte Rolf F.
Publication year - 2012
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.23212
Subject(s) - imaging phantom , nuclear magnetic resonance , spiral (railway) , hyperpolarization (physics) , dynamic imaging , physics , computer science , chemistry , nuclear magnetic resonance spectroscopy , biological system , optics , artificial intelligence , image processing , mathematics , image (mathematics) , biology , mathematical analysis , digital image processing
Metabolic imaging with hyperpolarized [1‐ 13 C]pyruvate offers the unique opportunity for a minimally invasive detection of cellular metabolism. Efficient and robust acquisition and reconstruction techniques are required for capturing the wealth of information present for the limited duration of the hyperpolarized state (∼1 min). In this study, the Dixon/IDEAL type of water–fat separation is expanded toward spectroscopic imaging of [1‐ 13 C]pyruvate and its down‐stream metabolites. For this purpose, the spectral–spatial encoding is based on single‐shot spiral image encoding and echo‐time shifting in between excitations for the chemical‐shift encoding. In addition, also a free‐induction decay spectrum is acquired and the obtained chemical‐shift prior knowledge is efficiently used in the reconstruction. The spectral–spatial reconstruction problem is found to efficiently separate into a chemical‐shift inversion followed by a spatial reconstruction. The method is successfully demonstrated for dynamic, multislice [1‐ 13 C]pyruvate metabolic MR imaging in phantom and in vivo rat experiments. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.