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Balanced steady‐state free precession fMRI with intravascular susceptibility contrast agent
Author(s) -
Zhou Iris Y.,
Cheung Matthew M.,
Lau Condon,
Chan Kevin C.,
Wu Ed X.
Publication year - 2012
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.23202
Subject(s) - echo planar imaging , cerebral blood flow , magnetic resonance imaging , blood volume , gradient echo , pulse sequence , nuclear magnetic resonance , medicine , radiology , physics
One major challenge in echo planar imaging‐based functional MRI (fMRI) is the susceptibility‐induced image distortion. In this study, a new cerebral blood volume‐weighted fMRI technique using distortion‐free balanced steady‐state free precession (bSSFP) sequence was proposed and its feasibility was investigated in rat brain at 7 Tesla. After administration of intravascular susceptibility contrast agent (monocrystalline iron oxide nanoparticle [MION] at 15 mg/kg), unilateral visual stimulation was presented using a block‐design paradigm. With repetition time/echo time = 3.8/1.9 ms and α = 18°, bSSFP fMRI was performed and compared with the conventional cerebral blood volume‐weighted fMRI using post‐MION gradient echo and spin echo echo planar imaging. The results showed that post‐MION bSSFP fMRI provides comparable sensitivity but with no severe image distortion and signal dropout. Robust negative responses were observed during stimulation and activation patterns were in excellent agreement with known neuroanatomy. Furthermore, the post‐MION bSSFP signal was observed to decrease significantly during hypercapnia challenge, indicating its sensitivity to cerebral blood volume changes. These findings demonstrated that post‐MION bSSFP fMRI is a promising alternative to conventional cerebral blood volume‐weighted fMRI. This technique is particularly suited for fMRI investigation of animal models at high field. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.