Premium
Differences in apparent diffusion coefficients of brain metabolites between grey and white matter in the human brain measured at 7 T
Author(s) -
Kan Hermien E.,
Techawiboonwong Aranee,
van Osch Matthias J. P.,
Versluis Maarten J.,
Deelchand Dinesh K.,
Henry PierreGilles,
Marjańska Małgorzata,
van Buchem Mark A.,
Webb Andrew G.,
Ronen Itamar
Publication year - 2012
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.23129
Subject(s) - white matter , grey matter , compartmentalization (fire protection) , diffusion mri , in vivo magnetic resonance spectroscopy , glutamate receptor , glutamine , chemistry , human brain , diffusion , nuclear magnetic resonance , neuroscience , psychology , biochemistry , magnetic resonance imaging , medicine , physics , amino acid , receptor , radiology , enzyme , thermodynamics
Diffusion weighted spectroscopy can provide microstructural information that is specific to compartmental geometry. So far, in human brain, apparent diffusion coefficients (ADCs) of only the metabolites N‐acetyl aspartate, creatine (tCr) and choline (tCho) have been assessed. High field MR at 7 T allows the collection and analysis of diffusion weighted spectroscopy data of additional metabolites of interest such as glutamate (Glu), N‐acetyl aspartyl glutamate, and glutamine (Gln), which are of interest due to their different compartmentalization and role in brain physiology. In this study, we performed 1 H diffusion weighted spectroscopy at 7 T using a diffusion‐weighted PRESS sequence in parietal white matter ( n = 6) and occipital grey matter ( n = 7). Data were analyzed using the LCmodel. ADCs could reliably be obtained of N‐acetyl aspartate, tCr, tCho, Glu, Gln in grey and white matter, and N‐acetyl aspartyl glutamate in white matter. Significant differences in ADC values were observed between grey and white matter for all metabolites. ADCs in grey matter were consistently lower than in white matter. These differences can probably be attributed to different compartmentalization as well as to the differential impact of diffusion time on ADC of different molecules under conditions of restricted diffusion. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.