Premium
Reorientation of fiber orientation distributions using apodized point spread functions
Author(s) -
Raffelt David,
Tournier JDonald,
Crozier Stuart,
Connelly Alan,
Salvado Olivier
Publication year - 2012
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.23058
Subject(s) - voxel , normalization (sociology) , spatial normalization , segmentation , artificial intelligence , deconvolution , computer science , image resolution , pattern recognition (psychology) , computer vision , diffusion mri , computation , white matter , algorithm , magnetic resonance imaging , medicine , sociology , anthropology , radiology
Using high angular resolution diffusion‐weighted images, spherical deconvolution enables multiple white matter fiber populations to be resolved within a single voxel by computing the fiber orientation distribution (FOD). Higher order information provided by FODs could improve several methods for investigating population differences in white matter, including image registration, voxel‐based analysis, atlas‐based segmentation and labeling, and group average fiber tractography. All of these methods require spatial normalization of FODs. In this article, a novel method to reorient the FOD is presented, which is an important step required for FOD spatial normalization. The proposed method was assessed using both qualitative and quantitative experiments, with numerical simulations and in vivo human data. Results demonstrate that the proposed method improves FOD reorientation accuracy, removes undesired artefacts, and decreases computation time compared to a previous approach. The utility of the proposed method is illustrated by nonlinear FOD spatial normalization of 10 human subjects. Accurate reorientation and normalization of FODs is a critical step toward investigating white matter tissue in the context of multiple fiber orientations. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.