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Phase‐based regional oxygen metabolism (PROM) using MRI
Author(s) -
Fan Audrey P.,
Benner Thomas,
Bolar Divya S.,
Rosen Bruce R.,
Adalsteinsson Elfar
Publication year - 2012
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.23050
Subject(s) - cerebral blood flow , cerebral veins , arterial spin labeling , nuclear magnetic resonance , magnetic resonance imaging , nuclear medicine , chemistry , medicine , physics , cardiology , radiology
Venous oxygen saturation ( Y v ) in cerebral veins and the cerebral metabolic rate of oxygen (CMRO 2 ) are important indicators for brain function and disease. Although MRI has been used for global measurements of these parameters, currently there is no recognized technique to quantify regional Y v and CMRO 2 using noninvasive imaging. This article proposes a technique to quantify CMRO 2 from independent MRI estimates of Y v and cerebral blood flow. The approach uses standard gradient‐echo and arterial spin labeling acquisitions to make these measurements. Using MR susceptometry on gradient‐echo phase images, Y v was quantified for candidate vein segments in gray matter that approximate a long cylinder parallel to the main magnetic field. Local cerebral blood flow for the identified vessel was determined from a corresponding region in the arterial spin labeling perfusion map. Fick's principle of arteriovenous difference was then used to quantify CMRO 2 locally around each vessel. Application of this method in young, healthy subjects provided gray matter averages of 59.6% ± 2.3% for Y v , 51.7 ± 6.4 mL/100 g/min for cerebral blood flow, and 158 ± 18 μmol/100 g/min for CMRO 2 (mean ± SD, n = 12), which is consistent with values previously reported by positron emission tomography and MRI. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.