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Dynamic contrast‐enhanced‐MRI of tumor hypoxia
Author(s) -
Egeland Tormod A.M.,
Gulliksrud Kristine,
Gaustad JonVidar,
Mathiesen Berit,
Rofstad Einar K.
Publication year - 2012
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.23014
Subject(s) - gadolinium , hypoxia (environmental) , tumor hypoxia , chemistry , nuclear medicine , dynamic contrast enhanced mri , pathology , magnetic resonance imaging , medicine , nuclear magnetic resonance , oxygen , radiology , radiation therapy , physics , organic chemistry
Patients with highly hypoxic primary tumors show increased frequency of locoregional treatment failure and poor survival rates and may benefit from particularly aggressive treatment. The potential of gadolinium diethylene‐triamine penta‐acetic acid‐based dynamic contrast‐enhanced‐MRI in assessing tumor hypoxia was investigated in this preclinical study. Xenografted tumors of eight human melanoma lines were subjected to dynamic contrast‐enhanced‐MRI and measurement of the fraction of radiobiologically hypoxic cells and the fraction of pimonidazole‐positive hypoxic cells. Tumor images of K trans (the volume transfer constant of gadolinium diethylene‐triamine penta‐acetic acid) and v e (the fractional distribution volume of gadolinium diethylene‐triamine penta‐acetic acid) were produced by pharmacokinetic analysis of the dynamic contrast‐enhanced‐MRI data, and K trans and v e frequency distributions of the non‐necrotic tumor tissue were established and related to the extent of hypoxia. Tumors showing high K trans values and high v e values had low fractions of hypoxic cells, whereas tumors showing both low K trans values and low v e values had high hypoxic fractions. K trans differentiated better between tumors with low and high hypoxic fractions than did v e . This study supports the current attempts to establish dynamic contrast‐enhanced‐MRI as a method for assessing the extent of hypoxia in human tumors, and it provides guidelines for the clinical development of valid assays. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.