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Rapid quantification of myocardial lipid content in humans using single breath‐hold 1 H MRS at 3 Tesla
Author(s) -
Rial Belen,
Robson Matthew D.,
Neubauer Stefan,
Schneider Jürgen E.
Publication year - 2011
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.23011
Subject(s) - reproducibility , nuclear magnetic resonance , chemistry , coefficient of variation , spectroscopy , nuclear medicine , analytical chemistry (journal) , medicine , chromatography , physics , quantum mechanics
A rapid, proton magnetic resonance spectroscopy method to evaluate human myocardial lipid levels in a single breath‐hold at 3 T using a commercial whole‐body system is presented. During a 10 s breath‐hold, water unsuppressed and suppressed spectra were acquired by two phased array coils using a short‐echo time spectroscopic stimulated echo (STEAM) sequence electrocardiogram‐triggered to mid‐diastole. Lipid‐to‐water ratios were obtained in the septum of 15 healthy volunteers, (0.46 ± 0.19)%. These results agreed well with ratios obtained from averaged spectra acquired in seven multiple breath‐holds, (0.45 ± 0.20)%, providing increased signal‐to‐noise ratio but requiring longer acquisition times. Excellent correlation was found between the two methods ( r = 0.94, P < 0.05). Reproducibility of 1 H MRS for measuring myocardial lipid levels in a short breath‐hold was acceptable in five repeated measurements within the same subject (coefficient of variation = 19%). Thus, single breath‐hold proton spectroscopy allows reliable and quick quantification of myocardial lipids at 3 T. Magn Reson Med, 2011. © 2011 Wiley‐Liss, Inc.