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Tumor imaging using hyperpolarized 13 C magnetic resonance spectroscopy
Author(s) -
Brindle Kevin M.,
Bohndiek Sarah E.,
Gallagher Ferdia A.,
Kettunen Mikko I.
Publication year - 2011
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22999
Subject(s) - magnetic resonance spectroscopic imaging , nuclear magnetic resonance , magnetic resonance imaging , hyperpolarization (physics) , chemistry , nuclear magnetic resonance spectroscopy , in vivo , molecular imaging , medicine , physics , biology , microbiology and biotechnology , radiology
Abstract Dynamic nuclear polarization is an emerging technique for increasing the sensitivity of magnetic resonance imaging and spectroscopy, particularly for low‐γ nuclei. The technique has been applied recently to a number of 13 C‐labeled cell metabolites in biological systems: the increase in signal‐to‐noise allows the spatial distribution of an injected molecule to be imaged as well as its metabolic product or products. This review highlights the most significant molecules investigated to date in preclinical cancer models, either in terms of their demonstrated metabolism in vivo or the biological processes that they can probe. In particular, label exchange between hyperpolarized 13 C‐labeled pyruvate and lactate, catalyzed by lactate dehydrogenase, has been shown to have a number of potential applications. Finally, techniques to image these molecules are also discussed as well as methods that may extend the lifetime of the hyperpolarized signal. Hyperpolarized magnetic resonance imaging and magnetic resonance spectroscopic imaging have shown great promise for the imaging of cancer in preclinical work, both for diagnosis and for monitoring therapy response. If the challenges in translating this technique to human imaging can be overcome, then it has the potential to significantly alter the management of cancer patients. Magn Reson Med, 2011. © 2011 Wiley‐Liss, Inc.