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Myocardial BOLD imaging at 3 T using quantitative T 2 : Application in a myocardial infarct model
Author(s) -
Ghugre Nilesh R.,
Ramanan Venkat,
Pop Mihaela,
Yang Yuesong,
Barry Jennifer,
Qiang Beiping,
Connelly Kim A.,
Dick Alexander J.,
Wright Graham A.
Publication year - 2011
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22972
Subject(s) - cardiology , medicine , myocardial infarction , vasodilation , revascularization , vasoconstriction , blood flow , coronary vasodilator , occlusion , coronary occlusion , endothelial dysfunction
Left ventricular remodeling as a result of acute myocardial infarction (AMI) is associated with significant morbidity, leading to cardiovascular dysfunction, disability, and death. Despite successful revascularization, coronary vasodilatory dysfunction has been shown in infarcted and remote myocardium of patients following AMI. Our study explored the utility of a T 2 ‐based blood‐oxygen‐level‐dependent approach in probing regional and longitudinal fluctuations in vasodilatory function in a porcine model of AMI at 3 T. Ten pigs underwent MRI in control state and at day 2, weeks 1–6 following 90 min occlusion followed by reperfusion. The remote myocardium exhibited vasodilatory dysfunction at weeks 1 and 2 that gradually recovered, whereas the infarct zone showed no vasodilatory alterations. Our study suggests that microvascular alterations occurring in infarcted and remote myocardium after AMI might serve as an indicator of adverse left ventricular remodeling. The blood‐oxygen‐level‐dependent technique using quantitative T 2 could potentially be a useful noninvasive tool to evaluate novel therapeutic strategies aimed at limiting vasoconstriction and improving coronary flow reserve after AMI. Magn Reson Med, 2011. © 2011 Wiley Periodicals, Inc.