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Assessment of early diastolic strain‐velocity temporal relationships using spatial modulation of magnetization with polarity alternating velocity encoding (SPAMM‐PAV)
Author(s) -
Zhang Ziheng,
Dione Donald P.,
Brown Peter B.,
Shapiro Erik M.,
Sinusas Albert J.,
Sampath Smita
Publication year - 2011
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22965
Subject(s) - pressure gradient , ventricle , apex (geometry) , diastole , basal (medicine) , hemodynamics , medicine , nuclear magnetic resonance , polarity (international relations) , cardiology , cardiac cycle , acceleration , materials science , anatomy , strain rate , physics , chemistry , blood pressure , mechanics , composite material , biochemistry , classical mechanics , insulin , cell
A novel MR imaging technique, spatial modulation of magnetization with polarity alternating velocity encoding (SPAMM‐PAV), is presented to simultaneously examine the left ventricular early diastolic temporal relationships between myocardial deformation and intra‐cavity hemodynamics with a high temporal resolution of 14 ms. This approach is initially evaluated in a dynamic flow and tissue mimicking phantom. A comparison of regional longitudinal strains and intra‐cavity pressure differences (integration of computed in‐plane pressure gradients within a selected region) in relation to mitral valve inflow velocities is performed in eight normal volunteers. Our results demonstrate that apical regions have higher strain rates (0.145 ± 0.005 %/ms) during the acceleration period of rapid filling compared to mid‐ventricular (0.114 ± 0.007 %/ms) and basal regions (0.088 ± 0.009 %/ms), and apical strain curves plateau at peak mitral inflow velocity. This pattern is reversed during the deceleration period, when the strain‐rates in the basal regions are the highest (0.027 ± 0.003 %/ms) due to ongoing basal stretching. A positive base‐to‐apex gradient in peak pressure difference is observed during acceleration, followed by a negative base‐to‐apex gradient during deceleration. These studies shed insight into the regional volumetric and pressure difference changes in the left ventricle during early diastolic filling. Magn Reson Med, 2011. © 2011 Wiley‐Liss, Inc.