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Test‐retest reliability and reproducibility of short‐echo‐time spectroscopic imaging of human brain at 3T
Author(s) -
Gasparovic Charles,
Bedrick Edward J.,
Mayer Andrew R.,
Yeo Ronald A.,
Chen HongJi,
Damaraju Eswar,
Calhoun Vince D.,
Jung Rex E.
Publication year - 2011
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22858
Subject(s) - reproducibility , intraclass correlation , creatine , nuclear medicine , magnetic resonance imaging , choline , medicine , white matter , coefficient of variation , nuclear magnetic resonance , chemistry , radiology , physics , chromatography
Abstract A 1 H magnetic resonance spectroscopic imaging study at 3T and short echo time was conducted to evaluate both the reproducibility, as measured by the interscan coefficient of variation (CV), and test‐retest reliability, as measured by the intraclass correlation coefficient (ICC), of measurements of glutamate (Glu), combined glutamate and glutamine (Glx), myo‐inositol (mI), N ‐acetylaspartate, creatine, and choline in 21 healthy subjects. The effect of partial volume correction on these measures and the relationship of reproducibility and reliability to data quality were also examined. A 1 H magnetic resonance spectroscopic imaging slice was prescribed above the lateral ventricles and single repeat scans were performed within 30 min to minimize physiologic variability. Interscan CVs based on all the voxels varied from 0.05 to 0.07 for N ‐acetylaspartate, creatine, and choline to 0.10–0.13 for mI, Glu, and Glx. Findings on the reproducibility of gray and white matter estimates of N ‐acetylaspartate, creatine, and choline are consistent with previous studies using longer echo times, with CVs in the range of 0.02–0.04 and ICC in the range of 0.65–0.90. CVs for Glu, Glx, and mI are much lower than reported in previous studies at 1.5T, while white matter mI (CV = 0.04, ICC = 0.93) and gray matter Glx (CV = 0.04, ICC = 0.68) demonstrated both high reproducibility and test‐retest reliability. Magn Reson Med, 2011. © 2011 Wiley‐Liss, Inc.