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On the relationship between seed‐based and ICA‐based measures of functional connectivity
Author(s) -
Joel Suresh E.,
Caffo Brian S.,
van Zijl Peter C. M.,
Pekar James J.
Publication year - 2011
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22818
Subject(s) - independent component analysis , functional magnetic resonance imaging , blood oxygenation , voxel , functional connectivity , pattern recognition (psychology) , computer science , correlation , component (thermodynamics) , resting state fmri , biological system , blood oxygen level dependent , magnetic resonance imaging , artificial intelligence , nuclear magnetic resonance , neuroscience , mathematics , psychology , physics , biology , medicine , geometry , radiology , thermodynamics
Brain functional connectivity (FC) refers to inter‐regional synchrony of low frequency fluctuations in blood oxygenation level dependent functional magnetic resonance imaging. FC has been evaluated both during task performance and in the “resting” state, yielding reports of FC differences correlated with behavior and diagnosis. Two methodologies are widely used for evaluating FC from blood oxygenation level dependent functional magnetic resonance imaging data: Temporal correlation with a specified seed voxel or small region of interest; and spatial independent component analysis. While results from seed‐based and independent component analysis methodologies are generally similar, they are conceptually different. This study is intended to elucidate and illustrate, qualitatively and quantitatively, the relationship between seed and independent component analysis derived measures of FC. Seed‐based FC measures are shown to be the sum of independent component analysis‐derived within network connectivities and between network connectivities. We present a simple simulation and an experiment on visuomotor activity that highlight this relationship between the two methods. Magn Reson Med, 2011. © 2011 Wiley‐Liss, Inc.