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Assessment of tissue edema in patients with acute myocardial infarction by computer‐assisted quantification of triple inversion recovery prepared MRI of the myocardium
Author(s) -
Johnstone R. I.,
Greenwood J. P.,
Biglands J. D.,
Plein S.,
Ridgway J. P.,
Radjenovic A.
Publication year - 2011
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22812
Subject(s) - edema , medicine , intraclass correlation , myocardial infarction , magnetic resonance imaging , cardiology , nuclear medicine , radiology , clinical psychology , psychometrics
Abstract The aim of this study was to design a computer algorithm to assess the extent of cardiac edema from triple inversion recovery MR images of the human left ventricular myocardium. Twenty‐one patients presenting with acute myocardial infarction were scanned within 48 h of the onset of symptoms. Eight patients were scanned a second time, 4 weeks after the initial event. Myocardial edema was detected in 27 of 29 studies using visual contour‐based manual segmentation. A reference standard, created from the segmentations of three raters by voxel‐wise majority voting, was compared to the edema mass estimates obtained using a newly developed computer algorithm. At baseline ( n = 20), the reference standard yielded an edema mass of 16.4 ± 15.0 g (mean ± SD) and the computer algorithm edema mass was 16.4 ± 12.6 g. At follow‐up ( n = 7), the reference standard edema mass was 7.1 ± 4.4 g compared to 16.3 ± 7.7 g at baseline. Computer algorithm estimates showed the same pattern of change with 5.7 ± 5.7 g at follow‐up compared to 20.8 ± 13.8 g at baseline. Although there was a significant degree of discrepancy between reference standard and computer algorithm estimates of edema mass in individual patients, their overall agreement was good, with intraclass correlation coefficient ICC(3, 1) = 0.753. Magn Reson Med, 2010. © 2011 Wiley‐Liss, Inc.