Premium
Influence of cell cycle phase on apparent diffusion coefficient in synchronized cells detected using temporal diffusion spectroscopy
Author(s) -
Xu Junzhong,
Xie Jingping,
Jourquin Jerome,
Colvin Daniel C.,
Does Mark D.,
Quaranta Vito,
Gore John C.
Publication year - 2011
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22704
Subject(s) - diffusion , effective diffusion coefficient , spin echo , nuclear magnetic resonance , phase (matter) , chemistry , materials science , physics , magnetic resonance imaging , thermodynamics , medicine , organic chemistry , radiology
The relationship between the apparent diffusion coefficient of tissue water measured by MR methods and the physiological status of cells is of particular relevance for better understanding and interpretation of diffusion‐weighted MRI. In addition, there is considerable interest in developing diffusion‐dependent imaging methods capable of providing novel information on tissue microstructure, including intracellular changes. To this end, both the conventional pulsed gradient spin–echo methods and the oscillating gradient spin–echo method, which probes diffusion over very short distance (< |