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Multiecho coarse voxel acquisition for neurofeedback fMRI
Author(s) -
Kuo Audrey Y.C.,
Chiew Mark,
Tam Fred,
Cunningham Charles,
Graham Simon J.
Publication year - 2011
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22674
Subject(s) - voxel , multislice , functional magnetic resonance imaging , nuclear magnetic resonance , temporal resolution , pulse sequence , magnetic resonance imaging , pulse (music) , physics , signal (programming language) , neurofeedback , computer science , artificial intelligence , neuroscience , optics , electroencephalography , psychology , medicine , detector , radiology , programming language
“Real‐time” functional magnetic resonance imaging is starting to be used in neurofeedback applications, enabling individuals to regulate their brain activity for therapeutic purposes. These applications use two‐dimensional multislice echo planar or spiral readouts to image the entire brain volume, often with a much smaller region of interest within the brain monitored for feedback purposes. Given that such brain activity should be sampled rapidly, it is worthwhile considering alternative functional magnetic resonance imaging pulse sequences that trade spatial resolution for temporal resolution. We developed a prototype sequence localizing a column of magnetization by outer volume saturation, from which densely sampled transverse relaxation time decays are obtained at coarse voxel locations using an asymmetric gradient echo train. For 5 × 20 × 20 mm3 voxels, 256 echoes are sampled at ∼1 msec and then combined in weighted summation to increase functional magnetic resonance imaging signal contrast. This multiecho coarse voxel pulse sequence is shown experimentally at 1.5 T to provide the same signal contrast to noise ratio as obtained by spiral imaging for a primary motor cortex region of interest, but with potential for enhanced temporal resolution. A neurofeedback experiment also illustrates measurement and calculation of functional magnetic resonance imaging signals within 1 sec, emphasizing the future potential of the approach. Magn Reson Med, 2011. © 2010 Wiley‐Liss, Inc.