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High resolution three‐dimensional cardiac perfusion imaging using compartment‐based k‐t principal component analysis
Author(s) -
Vitanis Viton,
Manka Robert,
Giese Daniel,
Pedersen Henrik,
Plein Sven,
Boesiger Peter,
Kozerke Sebastian
Publication year - 2011
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.22620
Subject(s) - principal component analysis , compartment (ship) , perfusion , temporal resolution , perfusion scanning , computer science , cardiac cycle , acceleration , dynamic contrast enhanced mri , image resolution , biomedical engineering , nuclear medicine , nuclear magnetic resonance , physics , artificial intelligence , magnetic resonance imaging , medicine , radiology , cardiology , optics , oceanography , classical mechanics , geology
Three‐dimensional myocardial perfusion imaging requires significant acceleration of data acquisition to achieve whole‐heart coverage with adequate spatial and temporal resolution. The present article introduces a compartment‐based k‐t principal component analysis reconstruction approach, which permits three‐dimensional perfusion imaging at 10‐fold nominal acceleration. Using numerical simulations, it is shown that the compartment‐based method results in accurate representations of dynamic signal intensity changes with significant improvements of temporal fidelity in comparison to conventional k‐t principal component analysis reconstructions. Comparison of the two methods based on rest and stress three‐dimensional perfusion data acquired with 2.3 × 2.3 × 10 mm 3 during a 225 msec acquisition window in patients confirms the findings and demonstrates the potential of compartment‐based k‐t principal component analysis for highly accelerated three‐dimensional perfusion imaging. Magn Reson Med, 2011. © 2010 Wiley‐Liss, Inc.